What Is Ergothioneine?
Ergothioneine (CAS 497-30-3, INCI: Ergothioneine) is a rare, naturally occurring sulfur-containing amino acid discovered in 1909. Unlike conventional antioxidants, it is accumulated selectively by cells via the OCTN1 transporter, allowing targeted protection where oxidative stress is highest. VeraVita supplies high-purity L-Ergothioneine as a white to off-white crystalline powder, standardized for cosmetic and nutraceutical formulations.
Mechanism of Action
Ergothioneine operates through a unique dual-mode defense system. First, it directly scavenges reactive oxygen species (ROS) and reactive nitrogen species (RNS) — including singlet oxygen, hydroxyl radicals, and peroxynitrite — with exceptional efficiency. Second, it regenerates other antioxidants such as vitamin C, vitamin E, and glutathione, effectively extending their functional lifespan within the cell.
Because OCTN1 expression is upregulated under oxidative and inflammatory conditions, Ergothioneine is preferentially delivered to tissues under stress — skin exposed to UV, aging organs, and inflamed microenvironments. This smart antioxidant behavior makes it fundamentally different from blanket free-radical scavengers.
Key Application Areas
- Anti-aging skincare: Shields fibroblasts from UV-induced collagen degradation and reduces wrinkle depth in topical formulations.
- Cellular longevity supplements: Supports mitochondrial health and reduces biomarkers of cellular senescence in oral delivery forms.
- UV protection & after-sun care: Mitigates photodamage by neutralizing singlet oxygen generated during sun exposure.
- Eye health formulations: Accumulates in ocular tissues to protect against blue light and age-related oxidative decline.
- Sports nutrition: Reduces exercise-induced oxidative stress and supports faster muscle recovery post-training.
VeraVita Supply Advantages
VeraVita Biotech supplies Ergothioneine with purity ≥99% (HPLC), backed by comprehensive COA and MSDS documentation available upon request. Our material is suitable for both cosmetic (INCI-listed) and dietary supplement applications, with OEM/ODM capsule, tablet, and powder blend services available. For samples, specifications, or bulk pricing, contact us at info@veravitabio.com.