What Is Ergothioneine?
Ergothioneine (CAS 497-30-3, INCI: Ergothioneine) is a naturally occurring sulfur-containing amino acid derived from histidine. Often called the “longevity vitamin,” it is biosynthesized by certain fungi and bacteria and concentrated in mushrooms. Unlike common antioxidants, Ergothioneine is uniquely and actively transported into human cells through the OCTN1 (SLC22A4) transporter, allowing it to accumulate precisely where oxidative stress is highest. VeraVita supplies high-purity Ergothioneine as a stable, water-soluble white crystalline powder suitable for both cosmetic and nutraceutical applications.
Mechanism of Action
Ergothioneine functions as a powerful, highly stable cytoprotectant. Its thiol group scavenges a broad spectrum of reactive oxygen species and singlet oxygen without itself being rapidly degraded, giving it a far longer functional half-life than vitamin C or glutathione. Because the OCTN1 transporter continuously pulls it into mitochondria, the nucleus, and erythrocytes, it delivers targeted defense against UV-induced and metabolic oxidative damage at the cellular level.
This targeted, self-renewing accumulation means even low-dose formulations deliver measurable photoprotective and anti-aging benefits — a key advantage for cost-sensitive product developers.
Key Application Areas
- Anti-aging skincare — reduces fine lines and improves skin radiance by protecting fibroblasts from oxidative stress.
- Sun care & after-sun — mitigates UV-induced erythema and DNA damage as a complementary active.
- Nutricosmetics & supplements — supports healthy aging and cellular energy through mitochondrial protection.
- Neuroprotection — crosses into the brain via OCTN1, researched for cognitive and age-related support.
- Sports & recovery — lowers exercise-induced oxidative markers and supports faster recovery.
VeraVita Supply & Partnership
VeraVita Biotech provides Ergothioneine at a guaranteed purity of ≥99%, with full COA and MSDS available on request. We support flexible OEM/ODM solutions — from raw-material supply to finished-format development — and maintain consistent batch-to-batch quality for scaling brands. For specifications, samples, or partnership inquiries, contact us at info@veravitabio.com.