What Is 3-O-Ethyl Ascorbic Acid?
3-O-Ethyl Ascorbic Acid (CAS 86404-04-8; INCI: 3-O-Ethyl Ascorbic Acid) is a next-generation vitamin C derivative engineered for stability and performance. By introducing an ethyl group at the third carbon position of the L-ascorbic acid molecule, this derivative resists the oxidation and discoloration that plague conventional vitamin C, retaining over 98% activity in accelerated stability testing. Its amphiphilic structure—both water- and oil-compatible—allows deep penetration through the stratum corneum, where skin enzymes gradually convert it into fully active vitamin C. Global demand reflects this advantage: the cosmetic-grade market is projected to grow from USD 795 million in 2026 to USD 1.28 billion by 2034.
How It Works
Once delivered into the skin, 3-O-Ethyl Ascorbic Acid inhibits tyrosinase—the key enzyme in melanin synthesis—helping to fade dark spots and promote an even, luminous tone. Unlike pure L-ascorbic acid, which requires a low pH (<3.5) and often stings, it remains stable and effective at pH 4.0–5.5, close to the skin’s natural pH, making it suitable for sensitive-skin formulations.
It also stimulates collagen synthesis and neutralizes free radicals generated by UV exposure, blue light, and pollution, supporting firmness, elasticity, and photoprotection while reducing UV-induced redness and inflammation.
Key Application Areas
- Vitamin C serums and brightening essences — reduces hyperpigmentation and dark spots for an even skin tone
- Anti-aging creams and lotions — supports collagen synthesis, firmness, and fine-line reduction
- Sun care and photoprotective products — complements UV filters with antioxidant defense against free radical damage
- Daily moisturizers and facial masks — stable at skin-friendly pH, non-sticky texture, suitable for sensitive skin
- Nutraceutical and functional food applications — a stable vitamin C nutrient enhancer for ingestible beauty and vitamin-enriched formulations
VeraVita Supply
VeraVita Biotech supplies high-purity 3-O-Ethyl Ascorbic Acid (≥99%, premium grades available) for cosmetic and nutraceutical manufacturers worldwide. Full documentation, including COA and MSDS, is available upon request, and we support OEM/ODM customization from sample development to bulk supply. For specifications, pricing, or a free sample, contact us at info@veravitabio.com.